CONVERSION OF OCTANOIC ACID TO RAT LIVER GLYCOGEN, STUDIED WITH C14,C13-LABELED OCTANOATE
نویسندگان
چکیده
منابع مشابه
Regulation of rat liver glycogen synthetase. Carboxylic acid activation of liver glycogen synthetase.
Rat liver glycogen synthetase is strongly stimulated by cellular carboxylic acids which are intermediates of glycolysis and the tricarboxylic acid cycle. Activation of glycogen synthetase by the carboxylic acids may coordinate hepatic glycogen deposition with the functional status of the tricarboxylic acid cycle. At physiological concentrations of the carboxylic acids, the I form is preferentia...
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Topper and Stetten (1) fed n-galactose-l-Cl4 by stomach tube to fasted rats and isolated glucose from the liver glycogen. About 90 per cent of the Cl4 was in C-l of the glucose unit of glycogen. They concluded that a direct epimerization of carbon 4 of the n-galactose occurred rather than a rupture of the carbon skeleton (1). However, any mechanism which removed C-l and which formed glycogen fr...
متن کاملConversion of galactose and glucose to liver glycogen in vivo.
Topper and Stetten (1) fed n-galactose-l-Cl4 by stomach tube to fasted rats and isolated glucose from the liver glycogen. About 90 per cent of the Cl4 was in C-l of the glucose unit of glycogen. They concluded that a direct epimerization of carbon 4 of the n-galactose occurred rather than a rupture of the carbon skeleton (1). However, any mechanism which removed C-l and which formed glycogen fr...
متن کاملThe oxidative metabolic pattern of mouse hepatoma C954 as studied with C14-labeled acetates, propionate, octanoate, and glucose.
Weinhouse and co-workers (39-43) have estab lished that the Krebs tricarboxylic acid cycle operates in a variety of experimental tumors and that fatty acid oxidation, believed to be non existent in tumors (9), provides 2-carbon frag ments for continuous operation of this cycle in neoplastic tissues. Our studies with the mouse hepatoma C954, carried by mice of the C57-Leaden strain, also led us ...
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Pyruvate has been shown to decrease the oxidation of palmitic acid by rat liver and kidney slices (l), but to have little influence on octanoate oxidation by liver slices (2, 3). Likewise, prior glucose administration decreased the rate of oxidation of palmitic acid by the rat in viva, but not that of octanoic acid (4). Glucose has also been reported to decrease the oxidation of serum lipides b...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1949
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)56567-4